Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 12234..12985 Replicon plasmid p130-1
Accession NZ_CP111009
Organism Escherichia coli strain J53-p130

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag ORI87_RS22850 Protein ID WP_004902249.1
Coordinates 12234..12716 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag ORI87_RS22855 Protein ID WP_004902250.1
Coordinates 12707..12985 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI87_RS22830 (ORI87_22830) 8633..9280 - 648 WP_014386537.1 EcsC family protein -
ORI87_RS22835 (ORI87_22835) 9307..10062 - 756 WP_004902235.1 DUF2971 domain-containing protein -
ORI87_RS22840 (ORI87_22840) 10163..10555 - 393 WP_045145491.1 hypothetical protein -
ORI87_RS22845 (ORI87_22845) 10660..11199 - 540 WP_004902239.1 hypothetical protein -
ORI87_RS22850 (ORI87_22850) 12234..12716 - 483 WP_004902249.1 GNAT family N-acetyltransferase Toxin
ORI87_RS22855 (ORI87_22855) 12707..12985 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
ORI87_RS22860 (ORI87_22860) 13104..13316 - 213 WP_266051389.1 hypothetical protein -
ORI87_RS22865 (ORI87_22865) 13424..13765 - 342 WP_004902257.1 hypothetical protein -
ORI87_RS22870 (ORI87_22870) 14539..14649 + 111 Protein_16 glutathione ABC transporter permease GsiC -
ORI87_RS22875 (ORI87_22875) 14733..16403 - 1671 WP_004902261.1 AMP-binding protein -
ORI87_RS22880 (ORI87_22880) 16384..17649 - 1266 WP_004210292.1 MSMEG_0569 family flavin-dependent oxidoreductase -
ORI87_RS22885 (ORI87_22885) 17667..17957 - 291 WP_011154627.1 MSMEG_0570 family nitrogen starvation response protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - rmpA / iroN / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 1..226559 226559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17689.52 Da        Isoelectric Point: 9.2033

>T264796 WP_004902249.1 NZ_CP111009:c12716-12234 [Escherichia coli]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNKVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT264796 WP_004902250.1 NZ_CP111009:c12985-12707 [Escherichia coli]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References