Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3886560..3887374 Replicon chromosome
Accession NZ_CP111008
Organism Escherichia coli strain J53-p130

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ORI87_RS19075 Protein ID WP_001054376.1
Coordinates 3886560..3886817 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ORI87_RS19080 Protein ID WP_001309181.1
Coordinates 3886829..3887374 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI87_RS19050 (3881848) 3881848..3882954 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
ORI87_RS19055 (3883019) 3883019..3883999 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ORI87_RS19060 (3884109) 3884109..3884314 + 206 Protein_3727 HNH endonuclease -
ORI87_RS19065 (3884582) 3884582..3885822 - 1241 Protein_3728 helicase YjhR -
ORI87_RS19070 (3885938) 3885938..3886069 + 132 WP_001309182.1 hypothetical protein -
ORI87_RS19075 (3886560) 3886560..3886817 + 258 WP_001054376.1 YjhX family toxin Toxin
ORI87_RS19080 (3886829) 3886829..3887374 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
ORI87_RS19085 (3887430) 3887430..3888176 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ORI87_RS19090 (3888345) 3888345..3888563 + 219 Protein_3733 hypothetical protein -
ORI87_RS19095 (3888601) 3888601..3888717 + 117 Protein_3734 VOC family protein -
ORI87_RS19100 (3888962) 3888962..3890083 + 1122 WP_000010829.1 M42 family metallopeptidase -
ORI87_RS19105 (3890080) 3890080..3890358 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
ORI87_RS19110 (3890370) 3890370..3891683 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 3879054..3895598 16544


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T264792 WP_001054376.1 NZ_CP111008:3886560-3886817 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT264792 WP_001309181.1 NZ_CP111008:3886829-3887374 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References