Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3311473..3312091 Replicon chromosome
Accession NZ_CP111008
Organism Escherichia coli strain J53-p130

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ORI87_RS16305 Protein ID WP_001291435.1
Coordinates 3311873..3312091 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ORI87_RS16300 Protein ID WP_000344800.1
Coordinates 3311473..3311847 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI87_RS16290 (3306562) 3306562..3307755 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ORI87_RS16295 (3307778) 3307778..3310927 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
ORI87_RS16300 (3311473) 3311473..3311847 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ORI87_RS16305 (3311873) 3311873..3312091 + 219 WP_001291435.1 HHA domain-containing protein Toxin
ORI87_RS16310 (3312263) 3312263..3312814 + 552 WP_000102564.1 maltose O-acetyltransferase -
ORI87_RS16315 (3312930) 3312930..3313400 + 471 WP_000136192.1 YlaC family protein -
ORI87_RS16320 (3313564) 3313564..3315114 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ORI87_RS16325 (3315156) 3315156..3315509 - 354 WP_000878140.1 DUF1428 domain-containing protein -
ORI87_RS16335 (3315888) 3315888..3316199 + 312 WP_000409911.1 MGMT family protein -
ORI87_RS16340 (3316230) 3316230..3316802 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264787 WP_001291435.1 NZ_CP111008:3311873-3312091 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT264787 WP_000344800.1 NZ_CP111008:3311473-3311847 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References