264786

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2232277..2232915 Replicon chromosome
Accession NZ_CP111008
Organism Escherichia coli strain J53-p130

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ORI87_RS10890 Protein ID WP_000813794.1
Coordinates 2232739..2232915 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ORI87_RS10885 Protein ID WP_001270286.1
Coordinates 2232277..2232693 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI87_RS10865 (2227429) 2227429..2228370 - 942 WP_001251304.1 ABC transporter permease -
ORI87_RS10870 (2228371) 2228371..2229384 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
ORI87_RS10875 (2229402) 2229402..2230547 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
ORI87_RS10880 (2230792) 2230792..2232198 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
ORI87_RS10885 (2232277) 2232277..2232693 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ORI87_RS10890 (2232739) 2232739..2232915 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ORI87_RS10895 (2233137) 2233137..2233367 + 231 WP_000494244.1 YncJ family protein -
ORI87_RS10900 (2233459) 2233459..2235420 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ORI87_RS10905 (2235493) 2235493..2236029 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
ORI87_RS10910 (2236121) 2236121..2237296 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T264786 WP_000813794.1 NZ_CP111008:c2232915-2232739 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT264786 WP_001270286.1 NZ_CP111008:c2232693-2232277 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References