Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 95960..96711 Replicon plasmid p131-1
Accession NZ_CP111005
Organism Escherichia coli strain J53-p131

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag ORI86_RS23355 Protein ID WP_004902249.1
Coordinates 95960..96442 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag ORI86_RS23360 Protein ID WP_004902250.1
Coordinates 96433..96711 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI86_RS23335 (ORI86_23335) 92359..93006 - 648 WP_014386537.1 EcsC family protein -
ORI86_RS23340 (ORI86_23340) 93033..93788 - 756 WP_004902235.1 DUF2971 domain-containing protein -
ORI86_RS23345 (ORI86_23345) 93889..94281 - 393 WP_045145491.1 hypothetical protein -
ORI86_RS23350 (ORI86_23350) 94386..94925 - 540 WP_004902239.1 hypothetical protein -
ORI86_RS23355 (ORI86_23355) 95960..96442 - 483 WP_004902249.1 GNAT family N-acetyltransferase Toxin
ORI86_RS23360 (ORI86_23360) 96433..96711 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
ORI86_RS23365 (ORI86_23365) 96830..97042 - 213 WP_266051389.1 hypothetical protein -
ORI86_RS23370 (ORI86_23370) 97150..97491 - 342 WP_004902257.1 hypothetical protein -
ORI86_RS23375 (ORI86_23375) 98265..98375 + 111 Protein_116 glutathione ABC transporter permease GsiC -
ORI86_RS23380 (ORI86_23380) 98459..100129 - 1671 WP_004902261.1 AMP-binding protein -
ORI86_RS23385 (ORI86_23385) 100110..101375 - 1266 WP_004210292.1 MSMEG_0569 family flavin-dependent oxidoreductase -
ORI86_RS23390 (ORI86_23390) 101393..101683 - 291 WP_011154627.1 MSMEG_0570 family nitrogen starvation response protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA14 iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 / rmpA / iroN / iroD / iroC / iroB 1..256283 256283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17689.52 Da        Isoelectric Point: 9.2033

>T264769 WP_004902249.1 NZ_CP111005:c96442-95960 [Escherichia coli]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNKVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT264769 WP_004902250.1 NZ_CP111005:c96711-96433 [Escherichia coli]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References