Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3886967..3887781 Replicon chromosome
Accession NZ_CP111004
Organism Escherichia coli strain J53-p131

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ORI86_RS19080 Protein ID WP_001054376.1
Coordinates 3886967..3887224 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ORI86_RS19085 Protein ID WP_001309181.1
Coordinates 3887236..3887781 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI86_RS19055 (3882255) 3882255..3883361 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
ORI86_RS19060 (3883426) 3883426..3884406 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ORI86_RS19065 (3884516) 3884516..3884721 + 206 Protein_3727 HNH endonuclease -
ORI86_RS19070 (3884989) 3884989..3886229 - 1241 Protein_3728 helicase YjhR -
ORI86_RS19075 (3886345) 3886345..3886476 + 132 WP_001309182.1 hypothetical protein -
ORI86_RS19080 (3886967) 3886967..3887224 + 258 WP_001054376.1 YjhX family toxin Toxin
ORI86_RS19085 (3887236) 3887236..3887781 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
ORI86_RS19090 (3887837) 3887837..3888583 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ORI86_RS19095 (3888752) 3888752..3888970 + 219 Protein_3733 hypothetical protein -
ORI86_RS19100 (3889008) 3889008..3889124 + 117 Protein_3734 VOC family protein -
ORI86_RS19105 (3889369) 3889369..3890490 + 1122 WP_000010829.1 M42 family metallopeptidase -
ORI86_RS19110 (3890487) 3890487..3890765 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
ORI86_RS19115 (3890777) 3890777..3892090 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 3879461..3896005 16544
- inside Genomic island - fimI / fimA / fimE / fimB 3876753..3896005 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T264764 WP_001054376.1 NZ_CP111004:3886967-3887224 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT264764 WP_001309181.1 NZ_CP111004:3887236-3887781 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References