Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3311880..3312498 Replicon chromosome
Accession NZ_CP111004
Organism Escherichia coli strain J53-p131

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ORI86_RS16310 Protein ID WP_001291435.1
Coordinates 3312280..3312498 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ORI86_RS16305 Protein ID WP_000344800.1
Coordinates 3311880..3312254 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI86_RS16295 (3306969) 3306969..3308162 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ORI86_RS16300 (3308185) 3308185..3311334 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
ORI86_RS16305 (3311880) 3311880..3312254 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ORI86_RS16310 (3312280) 3312280..3312498 + 219 WP_001291435.1 HHA domain-containing protein Toxin
ORI86_RS16315 (3312670) 3312670..3313221 + 552 WP_000102564.1 maltose O-acetyltransferase -
ORI86_RS16320 (3313337) 3313337..3313807 + 471 WP_000136192.1 YlaC family protein -
ORI86_RS16325 (3313971) 3313971..3315521 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ORI86_RS16330 (3315563) 3315563..3315916 - 354 WP_000878140.1 DUF1428 domain-containing protein -
ORI86_RS16340 (3316295) 3316295..3316606 + 312 WP_000409911.1 MGMT family protein -
ORI86_RS16345 (3316637) 3316637..3317209 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264759 WP_001291435.1 NZ_CP111004:3312280-3312498 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT264759 WP_000344800.1 NZ_CP111004:3311880-3312254 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References