Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 80544..81295 Replicon plasmid p133-1
Accession NZ_CP111000
Organism Escherichia coli strain J53-p133

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag ORI88_RS23245 Protein ID WP_004902249.1
Coordinates 80544..81026 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag ORI88_RS23250 Protein ID WP_004902250.1
Coordinates 81017..81295 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI88_RS23225 (ORI88_23225) 76943..77590 - 648 WP_014386537.1 EcsC family protein -
ORI88_RS23230 (ORI88_23230) 77617..78372 - 756 WP_004902235.1 DUF2971 domain-containing protein -
ORI88_RS23235 (ORI88_23235) 78473..78865 - 393 WP_045145491.1 hypothetical protein -
ORI88_RS23240 (ORI88_23240) 78970..79509 - 540 WP_004902239.1 hypothetical protein -
ORI88_RS23245 (ORI88_23245) 80544..81026 - 483 WP_004902249.1 GNAT family N-acetyltransferase Toxin
ORI88_RS23250 (ORI88_23250) 81017..81295 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
ORI88_RS23255 (ORI88_23255) 81414..81626 - 213 WP_266051389.1 hypothetical protein -
ORI88_RS23260 (ORI88_23260) 81734..82075 - 342 WP_004902257.1 hypothetical protein -
ORI88_RS23265 (ORI88_23265) 82849..82959 + 111 Protein_94 glutathione ABC transporter permease GsiC -
ORI88_RS23270 (ORI88_23270) 83043..84713 - 1671 WP_004902261.1 AMP-binding protein -
ORI88_RS23275 (ORI88_23275) 84694..85959 - 1266 WP_004210292.1 MSMEG_0569 family flavin-dependent oxidoreductase -
ORI88_RS23280 (ORI88_23280) 85977..86267 - 291 WP_011154627.1 MSMEG_0570 family nitrogen starvation response protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iucA / iucB / iucC / iucD / iutA / rmpA / rmpA2 / rmpA / iroN / iroD / iroC / iroB 1..226559 226559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17689.52 Da        Isoelectric Point: 9.2033

>T264741 WP_004902249.1 NZ_CP111000:c81026-80544 [Escherichia coli]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNKVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT264741 WP_004902250.1 NZ_CP111000:c81295-81017 [Escherichia coli]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References