Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2232503..2233141 Replicon chromosome
Accession NZ_CP110999
Organism Escherichia coli strain J53-p133

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ORI88_RS10890 Protein ID WP_000813794.1
Coordinates 2232965..2233141 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ORI88_RS10885 Protein ID WP_001270286.1
Coordinates 2232503..2232919 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI88_RS10865 (2227655) 2227655..2228596 - 942 WP_001251304.1 ABC transporter permease -
ORI88_RS10870 (2228597) 2228597..2229610 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
ORI88_RS10875 (2229628) 2229628..2230773 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
ORI88_RS10880 (2231018) 2231018..2232424 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
ORI88_RS10885 (2232503) 2232503..2232919 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ORI88_RS10890 (2232965) 2232965..2233141 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ORI88_RS10895 (2233363) 2233363..2233593 + 231 WP_000494244.1 YncJ family protein -
ORI88_RS10900 (2233685) 2233685..2235646 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ORI88_RS10905 (2235719) 2235719..2236255 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
ORI88_RS10910 (2236347) 2236347..2237522 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T264729 WP_000813794.1 NZ_CP110999:c2233141-2232965 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT264729 WP_001270286.1 NZ_CP110999:c2232919-2232503 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References