Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4097030..4097648 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ORI30_RS19720 Protein ID WP_001291435.1
Coordinates 4097030..4097248 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ORI30_RS19725 Protein ID WP_000344800.1
Coordinates 4097274..4097648 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS19685 (4092318) 4092318..4092890 + 573 WP_000779831.1 YbaY family lipoprotein -
ORI30_RS19690 (4092921) 4092921..4093232 - 312 WP_000409908.1 MGMT family protein -
ORI30_RS19700 (4093611) 4093611..4093964 + 354 WP_000878140.1 DUF1428 domain-containing protein -
ORI30_RS19705 (4094006) 4094006..4095556 - 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ORI30_RS19710 (4095720) 4095720..4096190 - 471 WP_000136192.1 YlaC family protein -
ORI30_RS19715 (4096306) 4096306..4096857 - 552 WP_000102539.1 maltose O-acetyltransferase -
ORI30_RS19720 (4097030) 4097030..4097248 - 219 WP_001291435.1 HHA domain-containing protein Toxin
ORI30_RS19725 (4097274) 4097274..4097648 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ORI30_RS19730 (4098194) 4098194..4101343 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
ORI30_RS19735 (4101366) 4101366..4102559 - 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264707 WP_001291435.1 NZ_CP110996:c4097248-4097030 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT264707 WP_000344800.1 NZ_CP110996:c4097648-4097274 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References