Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3198944..3199441 Replicon chromosome
Accession NZ_CP110996
Organism Escherichia coli strain XYEH3783

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag ORI30_RS15340 Protein ID WP_001173343.1
Coordinates 3199268..3199441 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag ORI30_RS15335 Protein ID WP_001312331.1
Coordinates 3198944..3199240 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI30_RS15315 (3195673) 3195673..3196392 - 720 WP_001540474.1 two-component system response regulator DcuR -
ORI30_RS15320 (3196389) 3196389..3198020 - 1632 WP_001216482.1 sensor histidine kinase -
ORI30_RS15325 (3198201) 3198201..3198431 + 231 WP_000373293.1 4Fe-4S mono-cluster protein YjdI -
ORI30_RS15330 (3198443) 3198443..3198715 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
ORI30_RS15335 (3198944) 3198944..3199240 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
ORI30_RS15340 (3199268) 3199268..3199441 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
ORI30_RS15345 (3199560) 3199560..3201077 - 1518 WP_000003806.1 lysine--tRNA ligase -
ORI30_RS15350 (3201314) 3201314..3202771 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3198944..3256451 57507


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T264697 WP_001173343.1 NZ_CP110996:3199268-3199441 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT264697 WP_001312331.1 NZ_CP110996:3198944-3199240 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References