26469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 867826..868408 Replicon chromosome
Accession NC_017312
Organism Enterococcus faecalis 62

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag EF62_RS04460 Protein ID WP_002355414.1
Coordinates 868100..868408 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag EF62_RS04455 Protein ID WP_002326825.1
Coordinates 867826..868098 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EF62_RS04435 (863507) 863507..865183 + 1677 WP_010709001.1 type IA DNA topoisomerase -
EF62_RS04445 (866669) 866669..867523 + 855 WP_002364921.1 ParA family protein -
EF62_RS04450 (867594) 867594..867809 + 216 WP_002355411.1 peptide-binding protein -
EF62_RS04455 (867826) 867826..868098 + 273 WP_002326825.1 antitoxin Antitoxin
EF62_RS04460 (868100) 868100..868408 + 309 WP_002355414.1 zeta toxin family protein Toxin
EF62_RS04465 (868488) 868488..868910 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
EF62_RS04470 (868961) 868961..869461 - 501 WP_002355415.1 HAD family hydrolase -
EF62_RS04475 (869466) 869466..870233 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
EF62_RS04480 (870721) 870721..871146 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
EF62_RS04485 (871163) 871163..871678 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
EF62_RS04490 (871689) 871689..872621 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage ClpL - 853275..868408 15133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T26469 WP_002355414.1 NC_017312:868100-868408 [Enterococcus faecalis 62]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T26469 NC_017312:868100-868408 [Enterococcus faecalis 62]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT26469 WP_002326825.1 NC_017312:867826-868098 [Enterococcus faecalis 62]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT26469 NC_017312:867826-868098 [Enterococcus faecalis 62]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References