Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4368123..4368620 Replicon chromosome
Accession NZ_CP110988
Organism Escherichia coli strain XYEH3314

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag ORI32_RS21275 Protein ID WP_001173343.1
Coordinates 4368123..4368296 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag ORI32_RS21280 Protein ID WP_000398619.1
Coordinates 4368324..4368620 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI32_RS21265 (4364788) 4364788..4366245 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
ORI32_RS21270 (4366482) 4366482..4367999 + 1518 WP_001295074.1 lysine--tRNA ligase -
ORI32_RS21275 (4368123) 4368123..4368296 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
ORI32_RS21280 (4368324) 4368324..4368620 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
ORI32_RS21285 (4368847) 4368847..4369119 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
ORI32_RS21290 (4369131) 4369131..4369361 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
ORI32_RS21295 (4369542) 4369542..4371173 + 1632 WP_001216477.1 sensor histidine kinase -
ORI32_RS21300 (4371170) 4371170..4371889 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T264681 WP_001173343.1 NZ_CP110988:c4368296-4368123 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT264681 WP_000398619.1 NZ_CP110988:c4368620-4368324 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References