Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3531352..3531970 Replicon chromosome
Accession NZ_CP110988
Organism Escherichia coli strain XYEH3314

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ORI32_RS17125 Protein ID WP_001291435.1
Coordinates 3531752..3531970 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ORI32_RS17120 Protein ID WP_000344800.1
Coordinates 3531352..3531726 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI32_RS17110 (3526441) 3526441..3527634 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ORI32_RS17115 (3527657) 3527657..3530806 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
ORI32_RS17120 (3531352) 3531352..3531726 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ORI32_RS17125 (3531752) 3531752..3531970 + 219 WP_001291435.1 HHA domain-containing protein Toxin
ORI32_RS17130 (3532142) 3532142..3532693 + 552 WP_000102564.1 maltose O-acetyltransferase -
ORI32_RS17135 (3532809) 3532809..3533279 + 471 WP_000136192.1 YlaC family protein -
ORI32_RS17140 (3533443) 3533443..3534993 + 1551 WP_064221513.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ORI32_RS17145 (3535035) 3535035..3535388 - 354 WP_000878140.1 DUF1428 domain-containing protein -
ORI32_RS17155 (3535767) 3535767..3536078 + 312 WP_000409911.1 MGMT family protein -
ORI32_RS17160 (3536109) 3536109..3536681 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264677 WP_001291435.1 NZ_CP110988:3531752-3531970 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT264677 WP_000344800.1 NZ_CP110988:3531352-3531726 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References