Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2414911..2415549 Replicon chromosome
Accession NZ_CP110988
Organism Escherichia coli strain XYEH3314

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag ORI32_RS11650 Protein ID WP_000813794.1
Coordinates 2415373..2415549 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag ORI32_RS11645 Protein ID WP_001270286.1
Coordinates 2414911..2415327 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI32_RS11625 (2410063) 2410063..2411004 - 942 WP_226762403.1 ABC transporter permease -
ORI32_RS11630 (2411005) 2411005..2412018 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
ORI32_RS11635 (2412036) 2412036..2413181 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
ORI32_RS11640 (2413426) 2413426..2414832 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
ORI32_RS11645 (2414911) 2414911..2415327 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
ORI32_RS11650 (2415373) 2415373..2415549 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
ORI32_RS11655 (2415771) 2415771..2416001 + 231 WP_000494244.1 YncJ family protein -
ORI32_RS11660 (2416093) 2416093..2418054 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
ORI32_RS11665 (2418127) 2418127..2418663 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
ORI32_RS11670 (2418755) 2418755..2419930 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T264675 WP_000813794.1 NZ_CP110988:c2415549-2415373 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT264675 WP_001270286.1 NZ_CP110988:c2415327-2414911 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References