Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4238504..4239001 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag ORI33_RS20365 Protein ID WP_001173343.1
Coordinates 4238504..4238677 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag ORI33_RS20370 Protein ID WP_000398619.1
Coordinates 4238705..4239001 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS20355 (4235174) 4235174..4236631 + 1458 WP_154167132.1 dipeptide/tripeptide permease DtpC -
ORI33_RS20360 (4236868) 4236868..4238385 + 1518 WP_155061476.1 lysine--tRNA ligase -
ORI33_RS20365 (4238504) 4238504..4238677 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
ORI33_RS20370 (4238705) 4238705..4239001 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
ORI33_RS20375 (4239228) 4239228..4239500 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
ORI33_RS20380 (4239512) 4239512..4239742 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
ORI33_RS20385 (4239923) 4239923..4241554 + 1632 WP_001216477.1 sensor histidine kinase -
ORI33_RS20390 (4241551) 4241551..4242270 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T264659 WP_001173343.1 NZ_CP110978:c4238677-4238504 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT264659 WP_000398619.1 NZ_CP110978:c4239001-4238705 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References