Detailed information of TA system TA264658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4088168..4089851
• Replicon: chromosome
• Accession: NZ_CP110978
• Organism: Escherichia coli strain XYEH3934

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: ORI33_RS19625
• Protein ID: WP_096310260.1
• Coordinates: 4088934..4089851 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: ORI33_RS19620
• Protein ID: WP_096310262.1
• Coordinates: 4088168..4088941 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ORI33_RS19605 (4084856)	4084856..4086109	+	1254	Protein_3833	protease Lon-related BREX system protein BrxL	-
ORI33_RS19610 (4086228)	4086228..4087577	+	1350	WP_024243516.1	phospholipase D-like domain-containing protein	-
ORI33_RS19615 (4087753)	4087753..4088084	-	332	Protein_3835	IS3 family transposase	-
ORI33_RS19620 (4088168)	4088168..4088941	+	774	WP_096310262.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ORI33_RS19625 (4088934)	4088934..4089851	+	918	WP_096310260.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ORI33_RS19630 (4090145)	4090145..4090312	+	168	WP_001356018.1	hypothetical protein	-
ORI33_RS19635 (4090365)	4090365..4091027	-	663	WP_000357928.1	hypothetical protein	-
ORI33_RS19640 (4091100)	4091100..4091738	-	639	Protein_3840	integrase arm-type DNA-binding domain-containing protein	-
ORI33_RS19650 (4092205)	4092205..4093224	+	1020	WP_112979019.1	NADPH-dependent aldehyde reductase Ahr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4082576..4091738	9162

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34905.98 Da
• Isoelectric Point: 4.7729

>T264658 WP_096310260.1 NZ_CP110978:4088934-4089851 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELEAQ
TGIRAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIAYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEVSLEELKEVPERMLSALKT
HFTQQDFDFLLSFKRGEPDWNIAPEPRIQNLPAVQWKLRNIGQMSEEKRAQSLEKLEKVMTEWLR

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29293.69 Da
• Isoelectric Point: 9.9889

>AT264658 WP_096310262.1 NZ_CP110978:4088168-4088941 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQNQCWLSVENKAILPKWFKEFPGVEWLMVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVAQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG

Nucleotide

• Length: 774 bp