264654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3475206..3476043 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag ORI33_RS16705 Protein ID WP_112978798.1
Coordinates 3475501..3476043 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag ORI33_RS16700 Protein ID WP_001297137.1
Coordinates 3475206..3475517 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS16675 (3470226) 3470226..3471173 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
ORI33_RS16680 (3471195) 3471195..3473186 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
ORI33_RS16685 (3473176) 3473176..3473790 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
ORI33_RS16690 (3473790) 3473790..3474119 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
ORI33_RS16695 (3474131) 3474131..3475021 + 891 WP_000971336.1 heme o synthase -
ORI33_RS16700 (3475206) 3475206..3475517 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
ORI33_RS16705 (3475501) 3475501..3476043 + 543 WP_112978798.1 GNAT family N-acetyltransferase Toxin
ORI33_RS16710 (3476099) 3476099..3477034 - 936 WP_096310067.1 tetratricopeptide repeat protein -
ORI33_RS16715 (3477442) 3477442..3478806 + 1365 WP_001000978.1 MFS transporter -
ORI33_RS16720 (3478934) 3478934..3479425 - 492 WP_001138904.1 nucleotide binding protein YajQ -
ORI33_RS16725 (3479593) 3479593..3480504 + 912 WP_000705853.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19776.97 Da        Isoelectric Point: 8.3395

>T264654 WP_112978798.1 NZ_CP110978:3475501-3476043 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGAYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT264654 WP_001297137.1 NZ_CP110978:3475206-3475517 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References