Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3441127..3441745 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag ORI33_RS16535 Protein ID WP_001291435.1
Coordinates 3441527..3441745 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag ORI33_RS16530 Protein ID WP_000344800.1
Coordinates 3441127..3441501 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS16520 (3436216) 3436216..3437409 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ORI33_RS16525 (3437432) 3437432..3440581 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
ORI33_RS16530 (3441127) 3441127..3441501 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
ORI33_RS16535 (3441527) 3441527..3441745 + 219 WP_001291435.1 HHA domain-containing protein Toxin
ORI33_RS16540 (3441917) 3441917..3442468 + 552 WP_000102564.1 maltose O-acetyltransferase -
ORI33_RS16545 (3442584) 3442584..3443054 + 471 WP_000136192.1 YlaC family protein -
ORI33_RS16550 (3443218) 3443218..3444768 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
ORI33_RS16555 (3444810) 3444810..3445163 - 354 WP_000878140.1 DUF1428 domain-containing protein -
ORI33_RS16565 (3445542) 3445542..3445853 + 312 WP_000409911.1 MGMT family protein -
ORI33_RS16570 (3445884) 3445884..3446456 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264653 WP_001291435.1 NZ_CP110978:3441527-3441745 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT264653 WP_000344800.1 NZ_CP110978:3441127-3441501 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References