Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869216..869870 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag ORI33_RS04250 Protein ID WP_000244777.1
Coordinates 869463..869870 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag ORI33_RS04245 Protein ID WP_000354046.1
Coordinates 869216..869482 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS04220 (864385) 864385..865128 + 744 WP_000951948.1 SDR family oxidoreductase -
ORI33_RS04225 (865185) 865185..866618 - 1434 WP_053900613.1 6-phospho-beta-glucosidase BglA -
ORI33_RS04230 (866663) 866663..866974 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
ORI33_RS04235 (867138) 867138..867797 + 660 WP_000250274.1 hemolysin III family protein -
ORI33_RS04240 (867993) 867993..868973 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
ORI33_RS04245 (869216) 869216..869482 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
ORI33_RS04250 (869463) 869463..869870 + 408 WP_000244777.1 protein YgfX Toxin
ORI33_RS04255 (869910) 869910..870431 - 522 WP_001055874.1 flavodoxin FldB -
ORI33_RS04260 (870543) 870543..871439 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
ORI33_RS04265 (871464) 871464..872174 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ORI33_RS04270 (872180) 872180..873913 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T264643 WP_000244777.1 NZ_CP110978:869463-869870 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT264643 WP_000354046.1 NZ_CP110978:869216-869482 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References