Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49622..50457 Replicon chromosome
Accession NZ_CP110978
Organism Escherichia coli strain XYEH3934

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2Y0VZS4
Locus tag ORI33_RS00255 Protein ID WP_032304079.1
Coordinates 49622..49999 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A369FMF5
Locus tag ORI33_RS00260 Protein ID WP_024188924.1
Coordinates 50089..50457 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORI33_RS00225 (44990) 44990..45913 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
ORI33_RS00230 (46024) 46024..47178 - 1155 WP_063625243.1 sugar efflux transporter -
ORI33_RS00235 (47605) 47605..47766 - 162 Protein_46 virulence RhuM family protein -
ORI33_RS00240 (47998) 47998..48843 - 846 WP_000065752.1 DUF4942 domain-containing protein -
ORI33_RS00245 (48928) 48928..49125 - 198 WP_000839243.1 DUF957 domain-containing protein -
ORI33_RS00250 (49137) 49137..49625 - 489 WP_000761714.1 DUF5983 family protein -
ORI33_RS00255 (49622) 49622..49999 - 378 WP_032304079.1 TA system toxin CbtA family protein Toxin
ORI33_RS00260 (50089) 50089..50457 - 369 WP_024188924.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ORI33_RS00265 (50531) 50531..50752 - 222 WP_073544043.1 DUF987 domain-containing protein -
ORI33_RS00270 (50821) 50821..51297 - 477 WP_143359950.1 RadC family protein -
ORI33_RS00275 (51313) 51313..51798 - 486 WP_000214415.1 antirestriction protein -
ORI33_RS00280 (51890) 51890..52708 - 819 WP_072643846.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14102.08 Da        Isoelectric Point: 7.9094

>T264640 WP_032304079.1 NZ_CP110978:c49999-49622 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13633.45 Da        Isoelectric Point: 6.7386

>AT264640 WP_024188924.1 NZ_CP110978:c50457-50089 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADTYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Y0VZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A369FMF5

References