Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4886675..4887191 Replicon chromosome
Accession NZ_CP110967
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-424/19

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NPX97_RS24230 Protein ID WP_002886902.1
Coordinates 4886675..4886959 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NPX97_RS24235 Protein ID WP_002886901.1
Coordinates 4886949..4887191 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX97_RS24205 (NPX97_24205) 4882159..4882422 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NPX97_RS24210 (NPX97_24210) 4882552..4882725 + 174 WP_002886906.1 hypothetical protein -
NPX97_RS24215 (NPX97_24215) 4882728..4883471 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NPX97_RS24220 (NPX97_24220) 4883828..4885966 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NPX97_RS24225 (NPX97_24225) 4886207..4886671 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NPX97_RS24230 (NPX97_24230) 4886675..4886959 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPX97_RS24235 (NPX97_24235) 4886949..4887191 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPX97_RS24240 (NPX97_24240) 4887269..4889179 - 1911 WP_004152270.1 PRD domain-containing protein -
NPX97_RS24245 (NPX97_24245) 4889202..4890356 - 1155 WP_002886900.1 lactonase family protein -
NPX97_RS24250 (NPX97_24250) 4890422..4891162 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T264632 WP_002886902.1 NZ_CP110967:c4886959-4886675 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT264632 WP_002886901.1 NZ_CP110967:c4887191-4886949 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References