Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2700047..2701635 Replicon chromosome
Accession NZ_CP110967
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-424/19

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NPX97_RS13455 Protein ID WP_002904792.1
Coordinates 2700313..2701635 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NPX97_RS13450 Protein ID WP_002904790.1
Coordinates 2700047..2700313 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX97_RS13425 (NPX97_13425) 2695197..2696120 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
NPX97_RS13430 (NPX97_13430) 2696101..2697255 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NPX97_RS13435 (NPX97_13435) 2697601..2698980 + 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NPX97_RS13440 (NPX97_13440) 2698958..2699458 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NPX97_RS13445 (NPX97_13445) 2699455..2699781 + 327 WP_002904788.1 hydroxyisourate hydrolase -
NPX97_RS13450 (NPX97_13450) 2700047..2700313 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NPX97_RS13455 (NPX97_13455) 2700313..2701635 + 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NPX97_RS13460 (NPX97_13460) 2701652..2702944 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NPX97_RS13465 (NPX97_13465) 2703086..2704090 - 1005 WP_002904798.1 fimbrial protein -
NPX97_RS13470 (NPX97_13470) 2704078..2706579 - 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T264629 WP_002904792.1 NZ_CP110967:2700313-2701635 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT264629 WP_002904790.1 NZ_CP110967:2700047-2700313 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References