Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5251551..5252176 Replicon chromosome
Accession NZ_CP110962
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-422/19

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NPY13_RS26040 Protein ID WP_002882817.1
Coordinates 5251551..5251934 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NPY13_RS26045 Protein ID WP_004150355.1
Coordinates 5251934..5252176 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY13_RS26025 (NPY13_26025) 5248917..5249819 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NPY13_RS26030 (NPY13_26030) 5249816..5250451 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NPY13_RS26035 (NPY13_26035) 5250448..5251377 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NPY13_RS26040 (NPY13_26040) 5251551..5251934 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NPY13_RS26045 (NPY13_26045) 5251934..5252176 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NPY13_RS26050 (NPY13_26050) 5252381..5253298 + 918 WP_002882812.1 alpha/beta hydrolase -
NPY13_RS26055 (NPY13_26055) 5253312..5254253 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NPY13_RS26060 (NPY13_26060) 5254298..5254735 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NPY13_RS26065 (NPY13_26065) 5254732..5255592 - 861 WP_002882807.1 virulence factor BrkB family protein -
NPY13_RS26070 (NPY13_26070) 5255586..5256185 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T264619 WP_002882817.1 NZ_CP110962:c5251934-5251551 [Klebsiella pneumoniae subsp. pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT264619 WP_004150355.1 NZ_CP110962:c5252176-5251934 [Klebsiella pneumoniae subsp. pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References