Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2721497..2723085 Replicon chromosome
Accession NZ_CP110962
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-422/19

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NPY13_RS13615 Protein ID WP_002904792.1
Coordinates 2721497..2722819 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NPY13_RS13620 Protein ID WP_002904790.1
Coordinates 2722819..2723085 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY13_RS13600 (NPY13_13600) 2716553..2719054 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
NPY13_RS13605 (NPY13_13605) 2719042..2720046 + 1005 WP_002904798.1 fimbrial protein -
NPY13_RS13610 (NPY13_13610) 2720188..2721480 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NPY13_RS13615 (NPY13_13615) 2721497..2722819 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NPY13_RS13620 (NPY13_13620) 2722819..2723085 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NPY13_RS13625 (NPY13_13625) 2723351..2723677 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NPY13_RS13630 (NPY13_13630) 2723674..2724174 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NPY13_RS13635 (NPY13_13635) 2724152..2725531 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NPY13_RS13640 (NPY13_13640) 2725877..2727031 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NPY13_RS13645 (NPY13_13645) 2727012..2727935 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T264614 WP_002904792.1 NZ_CP110962:c2722819-2721497 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT264614 WP_002904790.1 NZ_CP110962:c2723085-2722819 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References