Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872922..873579 Replicon chromosome
Accession NZ_CP110962
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-422/19

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NPY13_RS04405 Protein ID WP_002916310.1
Coordinates 873169..873579 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NPY13_RS04400 Protein ID WP_002916312.1
Coordinates 872922..873188 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY13_RS04375 (NPY13_04375) 868078..869511 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NPY13_RS04380 (NPY13_04380) 869630..870358 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NPY13_RS04385 (NPY13_04385) 870408..870719 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NPY13_RS04390 (NPY13_04390) 870883..871542 + 660 WP_002916317.1 hemolysin III family protein -
NPY13_RS04395 (NPY13_04395) 871693..872676 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NPY13_RS04400 (NPY13_04400) 872922..873188 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NPY13_RS04405 (NPY13_04405) 873169..873579 + 411 WP_002916310.1 protein YgfX Toxin
NPY13_RS04410 (NPY13_04410) 873586..874107 - 522 WP_002916308.1 flavodoxin FldB -
NPY13_RS04415 (NPY13_04415) 874208..875104 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NPY13_RS04420 (NPY13_04420) 875127..875840 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPY13_RS04425 (NPY13_04425) 875846..877579 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T264609 WP_002916310.1 NZ_CP110962:873169-873579 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT264609 WP_002916312.1 NZ_CP110962:872922-873188 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References