Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4760331..4760847 Replicon chromosome
Accession NZ_CP110957
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-395/19

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NPY03_RS23695 Protein ID WP_002886902.1
Coordinates 4760331..4760615 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NPY03_RS23700 Protein ID WP_002886901.1
Coordinates 4760605..4760847 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY03_RS23670 (NPY03_23670) 4755815..4756078 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NPY03_RS23675 (NPY03_23675) 4756208..4756381 + 174 WP_002886906.1 hypothetical protein -
NPY03_RS23680 (NPY03_23680) 4756384..4757127 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NPY03_RS23685 (NPY03_23685) 4757484..4759622 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NPY03_RS23690 (NPY03_23690) 4759863..4760327 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NPY03_RS23695 (NPY03_23695) 4760331..4760615 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPY03_RS23700 (NPY03_23700) 4760605..4760847 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPY03_RS23705 (NPY03_23705) 4760925..4762835 - 1911 WP_004152270.1 PRD domain-containing protein -
NPY03_RS23710 (NPY03_23710) 4762858..4764012 - 1155 WP_002886900.1 lactonase family protein -
NPY03_RS23715 (NPY03_23715) 4764078..4764818 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T264601 WP_002886902.1 NZ_CP110957:c4760615-4760331 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT264601 WP_002886901.1 NZ_CP110957:c4760847-4760605 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References