Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4919266..4920947 Replicon chromosome
Accession NZ_CP110952
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-394/19

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NPY09_RS24510 Protein ID WP_002885155.1
Coordinates 4919266..4920183 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NPY09_RS24515 Protein ID WP_004151732.1
Coordinates 4920189..4920947 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY09_RS24490 (NPY09_24490) 4914572..4916092 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NPY09_RS24495 (NPY09_24495) 4916089..4917087 + 999 WP_002885172.1 ribose ABC transporter permease -
NPY09_RS24500 (NPY09_24500) 4917118..4918059 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NPY09_RS24505 (NPY09_24505) 4918134..4919141 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NPY09_RS24510 (NPY09_24510) 4919266..4920183 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NPY09_RS24515 (NPY09_24515) 4920189..4920947 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NPY09_RS24520 (NPY09_24520) 4921033..4921761 - 729 WP_002885152.1 response regulator transcription factor -
NPY09_RS24525 (NPY09_24525) 4922034..4924181 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NPY09_RS24530 (NPY09_24530) 4924411..4925097 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T264586 WP_002885155.1 NZ_CP110952:c4920183-4919266 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT264586 WP_004151732.1 NZ_CP110952:c4920947-4920189 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References