Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2721599..2723187 Replicon chromosome
Accession NZ_CP110952
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-394/19

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NPY09_RS13620 Protein ID WP_002904792.1
Coordinates 2721599..2722921 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NPY09_RS13625 Protein ID WP_002904790.1
Coordinates 2722921..2723187 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY09_RS13605 (NPY09_13605) 2716655..2719156 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
NPY09_RS13610 (NPY09_13610) 2719144..2720148 + 1005 WP_002904798.1 fimbrial protein -
NPY09_RS13615 (NPY09_13615) 2720290..2721582 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NPY09_RS13620 (NPY09_13620) 2721599..2722921 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NPY09_RS13625 (NPY09_13625) 2722921..2723187 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NPY09_RS13630 (NPY09_13630) 2723453..2723779 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NPY09_RS13635 (NPY09_13635) 2723776..2724276 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NPY09_RS13640 (NPY09_13640) 2724254..2725633 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NPY09_RS13645 (NPY09_13645) 2725979..2727133 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NPY09_RS13650 (NPY09_13650) 2727114..2728037 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T264582 WP_002904792.1 NZ_CP110952:c2722921-2721599 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT264582 WP_002904790.1 NZ_CP110952:c2723187-2722921 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References