264551

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4418097..4418754 Replicon chromosome
Accession NZ_CP110941
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1873/18

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NPY10_RS21780 Protein ID WP_002916310.1
Coordinates 4418097..4418507 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NPY10_RS21785 Protein ID WP_002916312.1
Coordinates 4418488..4418754 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY10_RS21760 (NPY10_21760) 4414097..4415830 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
NPY10_RS21765 (NPY10_21765) 4415836..4416549 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPY10_RS21770 (NPY10_21770) 4416572..4417468 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NPY10_RS21775 (NPY10_21775) 4417569..4418090 + 522 WP_002916308.1 flavodoxin FldB -
NPY10_RS21780 (NPY10_21780) 4418097..4418507 - 411 WP_002916310.1 protein YgfX Toxin
NPY10_RS21785 (NPY10_21785) 4418488..4418754 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NPY10_RS21790 (NPY10_21790) 4419000..4419983 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NPY10_RS21795 (NPY10_21795) 4420134..4420793 - 660 WP_002916317.1 hemolysin III family protein -
NPY10_RS21800 (NPY10_21800) 4420957..4421268 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NPY10_RS21805 (NPY10_21805) 4421318..4422046 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NPY10_RS21810 (NPY10_21810) 4422165..4423598 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T264551 WP_002916310.1 NZ_CP110941:c4418507-4418097 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT264551 WP_002916312.1 NZ_CP110941:c4418754-4418488 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References