Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 350365..352046 Replicon chromosome
Accession NZ_CP110941
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1873/18

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NPY10_RS01650 Protein ID WP_002885155.1
Coordinates 351129..352046 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NPY10_RS01645 Protein ID WP_004151732.1
Coordinates 350365..351123 (+) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY10_RS01630 (NPY10_01630) 346215..346901 - 687 WP_004151733.1 tetratricopeptide repeat protein -
NPY10_RS01635 (NPY10_01635) 347131..349278 - 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NPY10_RS01640 (NPY10_01640) 349551..350279 + 729 WP_002885152.1 response regulator transcription factor -
NPY10_RS01645 (NPY10_01645) 350365..351123 + 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NPY10_RS01650 (NPY10_01650) 351129..352046 + 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NPY10_RS01655 (NPY10_01655) 352171..353178 - 1008 WP_004151731.1 carbohydrate kinase family protein -
NPY10_RS01660 (NPY10_01660) 353253..354194 - 942 WP_002885156.1 ABC transporter substrate-binding protein -
NPY10_RS01665 (NPY10_01665) 354225..355223 - 999 WP_002885172.1 ribose ABC transporter permease -
NPY10_RS01670 (NPY10_01670) 355220..356740 - 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T264542 WP_002885155.1 NZ_CP110941:351129-352046 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT264542 WP_004151732.1 NZ_CP110941:350365-351123 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References