264535

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4417343..4418000 Replicon chromosome
Accession NZ_CP110936
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1736/18

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NPY06_RS21795 Protein ID WP_002916310.1
Coordinates 4417343..4417753 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NPY06_RS21800 Protein ID WP_002916312.1
Coordinates 4417734..4418000 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY06_RS21775 (NPY06_21775) 4413343..4415076 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
NPY06_RS21780 (NPY06_21780) 4415082..4415795 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPY06_RS21785 (NPY06_21785) 4415818..4416714 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NPY06_RS21790 (NPY06_21790) 4416815..4417336 + 522 WP_002916308.1 flavodoxin FldB -
NPY06_RS21795 (NPY06_21795) 4417343..4417753 - 411 WP_002916310.1 protein YgfX Toxin
NPY06_RS21800 (NPY06_21800) 4417734..4418000 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NPY06_RS21805 (NPY06_21805) 4418246..4419229 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NPY06_RS21810 (NPY06_21810) 4419380..4420039 - 660 WP_002916317.1 hemolysin III family protein -
NPY06_RS21815 (NPY06_21815) 4420203..4420514 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NPY06_RS21820 (NPY06_21820) 4420564..4421292 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NPY06_RS21825 (NPY06_21825) 4421411..4422844 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T264535 WP_002916310.1 NZ_CP110936:c4417753-4417343 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT264535 WP_002916312.1 NZ_CP110936:c4418000-4417734 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References