Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2606696..2608284 Replicon chromosome
Accession NZ_CP110936
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1736/18

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag NPY06_RS12820 Protein ID WP_002904792.1
Coordinates 2606962..2608284 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NPY06_RS12815 Protein ID WP_002904790.1
Coordinates 2606696..2606962 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY06_RS12790 (NPY06_12790) 2601846..2602769 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
NPY06_RS12795 (NPY06_12795) 2602750..2603904 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NPY06_RS12800 (NPY06_12800) 2604250..2605629 + 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
NPY06_RS12805 (NPY06_12805) 2605607..2606107 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NPY06_RS12810 (NPY06_12810) 2606104..2606430 + 327 WP_002904788.1 hydroxyisourate hydrolase -
NPY06_RS12815 (NPY06_12815) 2606696..2606962 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NPY06_RS12820 (NPY06_12820) 2606962..2608284 + 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
NPY06_RS12825 (NPY06_12825) 2608301..2609593 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NPY06_RS12830 (NPY06_12830) 2609735..2610739 - 1005 WP_002904798.1 fimbrial protein -
NPY06_RS12835 (NPY06_12835) 2610727..2613228 - 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T264530 WP_002904792.1 NZ_CP110936:2606962-2608284 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT264530 WP_002904790.1 NZ_CP110936:2606696-2606962 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References