Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1226398..1227017 Replicon chromosome
Accession NZ_CP110936
Organism Klebsiella pneumoniae subsp. pneumoniae strain LC-1736/18

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NPY06_RS05915 Protein ID WP_002892050.1
Coordinates 1226398..1226616 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag NPY06_RS05920 Protein ID WP_002892066.1
Coordinates 1226643..1227017 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPY06_RS05880 (NPY06_05880) 1222445..1222708 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
NPY06_RS05885 (NPY06_05885) 1222708..1222848 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
NPY06_RS05890 (NPY06_05890) 1222845..1223543 - 699 WP_002892021.1 GNAT family protein -
NPY06_RS05895 (NPY06_05895) 1223644..1225095 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
NPY06_RS05900 (NPY06_05900) 1225070..1225540 - 471 WP_002892026.1 YlaC family protein -
NPY06_RS05905 (NPY06_05905) 1225561..1225701 + 141 WP_004147370.1 hypothetical protein -
NPY06_RS05910 (NPY06_05910) 1225673..1226239 - 567 WP_002892030.1 maltose O-acetyltransferase -
NPY06_RS05915 (NPY06_05915) 1226398..1226616 - 219 WP_002892050.1 HHA domain-containing protein Toxin
NPY06_RS05920 (NPY06_05920) 1226643..1227017 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
NPY06_RS05925 (NPY06_05925) 1227503..1230649 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
NPY06_RS05930 (NPY06_05930) 1230672..1231865 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264529 WP_002892050.1 NZ_CP110936:c1226616-1226398 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT264529 WP_002892066.1 NZ_CP110936:c1227017-1226643 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References