Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4128398..4128914 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag ORG43_RS20325 Protein ID WP_000220578.1
Coordinates 4128398..4128682 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag ORG43_RS20330 Protein ID WP_000212724.1
Coordinates 4128672..4128914 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS20310 (4123518) 4123518..4125166 + 1649 Protein_3974 alpha,alpha-phosphotrehalase -
ORG43_RS20315 (4125575) 4125575..4127713 + 2139 WP_001541406.1 anaerobic ribonucleoside-triphosphate reductase -
ORG43_RS20320 (4127930) 4127930..4128394 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ORG43_RS20325 (4128398) 4128398..4128682 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ORG43_RS20330 (4128672) 4128672..4128914 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ORG43_RS20335 (4128992) 4128992..4130925 - 1934 Protein_3979 BglG family transcription antiterminator -
ORG43_RS20340 (4130942) 4130942..4131682 - 741 WP_000779257.1 KDGP aldolase family protein -
ORG43_RS20345 (4131679) 4131679..4132797 - 1119 WP_038394077.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
ORG43_RS20350 (4132781) 4132781..4133914 - 1134 WP_000459940.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T264522 WP_000220578.1 NZ_CP110934:c4128682-4128398 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT264522 WP_000212724.1 NZ_CP110934:c4128914-4128672 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References