Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3368438..3369058 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag ORG43_RS16660 Protein ID WP_001280991.1
Coordinates 3368840..3369058 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag ORG43_RS16655 Protein ID WP_000344807.1
Coordinates 3368438..3368812 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS16645 (3363577) 3363577..3364770 + 1194 WP_023235518.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ORG43_RS16650 (3364793) 3364793..3367942 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
ORG43_RS16655 (3368438) 3368438..3368812 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
ORG43_RS16660 (3368840) 3368840..3369058 + 219 WP_001280991.1 HHA domain-containing protein Toxin
ORG43_RS16665 (3369237) 3369237..3369788 + 552 WP_001278793.1 maltose O-acetyltransferase -
ORG43_RS16670 (3369906) 3369906..3370376 + 471 WP_000136183.1 YlaC family protein -
ORG43_RS16675 (3370432) 3370432..3370572 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
ORG43_RS16680 (3370578) 3370578..3370838 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
ORG43_RS16685 (3371063) 3371063..3372472 + 1410 WP_038393950.1 EAL domain-containing protein -
ORG43_RS16695 (3372703) 3372703..3373092 + 390 WP_000961285.1 MGMT family protein -
ORG43_RS16700 (3373125) 3373125..3373694 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T264519 WP_001280991.1 NZ_CP110934:3368840-3369058 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT264519 WP_000344807.1 NZ_CP110934:3368438-3368812 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References