Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 950190..951004 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag ORG43_RS04550 Protein ID WP_000971655.1
Coordinates 950190..950717 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag ORG43_RS04555 Protein ID WP_000855694.1
Coordinates 950714..951004 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS04520 (946489) 946489..946887 + 399 Protein_885 cytoplasmic protein -
ORG43_RS04525 (947078) 947078..947317 + 240 Protein_886 hypothetical protein -
ORG43_RS04530 (947474) 947474..948142 + 669 WP_001540791.1 hypothetical protein -
ORG43_RS04535 (948169) 948169..948663 + 495 WP_001540790.1 hypothetical protein -
ORG43_RS04540 (948908) 948908..949564 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
ORG43_RS04545 (949902) 949902..950117 + 216 Protein_890 IS5/IS1182 family transposase -
ORG43_RS04550 (950190) 950190..950717 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
ORG43_RS04555 (950714) 950714..951004 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
ORG43_RS04560 (951274) 951274..951459 - 186 Protein_893 IS3 family transposase -
ORG43_RS04565 (951877) 951877..952320 - 444 WP_000715102.1 SPI-1 type III secretion system invasion lipoprotein InvH -
ORG43_RS04570 (952776) 952776..953426 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
ORG43_RS04575 (953423) 953423..955111 + 1689 WP_001540787.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 949977..958739 8762
- flank IS/Tn - - 949977..950117 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T264513 WP_000971655.1 NZ_CP110934:c950717-950190 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT264513 WP_000855694.1 NZ_CP110934:c951004-950714 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References