Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 815157..815817 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag ORG43_RS03865 Protein ID WP_000244756.1
Coordinates 815157..815570 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag ORG43_RS03870 Protein ID WP_000351186.1
Coordinates 815551..815817 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS03845 (811098) 811098..812831 - 1734 WP_000813392.1 single-stranded-DNA-specific exonuclease RecJ -
ORG43_RS03850 (812837) 812837..813550 - 714 WP_001540860.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ORG43_RS03855 (813574) 813574..814470 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
ORG43_RS03860 (814583) 814583..815104 + 522 WP_001055885.1 flavodoxin FldB -
ORG43_RS03865 (815157) 815157..815570 - 414 WP_000244756.1 protein YgfX Toxin
ORG43_RS03870 (815551) 815551..815817 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
ORG43_RS03875 (816067) 816067..817047 + 981 WP_000874173.1 tRNA-modifying protein YgfZ -
ORG43_RS03880 (817163) 817163..817822 - 660 WP_023235227.1 hemolysin III family protein -
ORG43_RS03885 (817986) 817986..818297 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
ORG43_RS03890 (818455) 818455..819888 + 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T264512 WP_000244756.1 NZ_CP110934:c815570-815157 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT264512 WP_000351186.1 NZ_CP110934:c815817-815551 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References