264511

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 804272..804897 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ORG43_RS03800 Protein ID WP_000911337.1
Coordinates 804272..804670 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag ORG43_RS03805 Protein ID WP_000557545.1
Coordinates 804670..804897 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS03785 (800948) 800948..801532 - 585 WP_001244638.1 fimbrial protein -
ORG43_RS03790 (802251) 802251..802883 - 633 WP_001540855.1 YfdX family protein -
ORG43_RS03795 (802930) 802930..803466 - 537 WP_001038500.1 STM3031 family outer membrane protein -
ORG43_RS03800 (804272) 804272..804670 - 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
ORG43_RS03805 (804670) 804670..804897 - 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
ORG43_RS03810 (805106) 805106..805357 + 252 WP_001540858.1 hypothetical protein -
ORG43_RS03815 (805632) 805632..806439 + 808 Protein_747 DUF1460 domain-containing protein -
ORG43_RS03825 (806724) 806724..807482 - 759 WP_000244328.1 amidase activator ActS -
ORG43_RS03830 (807747) 807747..808292 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
ORG43_RS03835 (808368) 808368..809885 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 795875..806439 10564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T264511 WP_000911337.1 NZ_CP110934:c804670-804272 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT264511 WP_000557545.1 NZ_CP110934:c804897-804670 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References