Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 301740..302531 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag ORG43_RS01365 Protein ID WP_000369560.1
Coordinates 302013..302531 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag ORG43_RS01360 Protein ID WP_001275017.1
Coordinates 301740..302009 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS01340 (297321) 297321..297989 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
ORG43_RS01345 (297982) 297982..299037 + 1056 WP_001079363.1 permease-like cell division protein FtsX -
ORG43_RS01350 (299283) 299283..300137 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
ORG43_RS01355 (300459) 300459..301562 + 1104 WP_001535347.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
ORG43_RS01360 (301740) 301740..302009 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
ORG43_RS01365 (302013) 302013..302531 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
ORG43_RS01370 (302528) 302528..302911 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
ORG43_RS01375 (303333) 303333..304436 + 1104 WP_023235350.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
ORG43_RS01380 (304496) 304496..305422 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
ORG43_RS01385 (305419) 305419..306696 + 1278 WP_001541045.1 branched chain amino acid ABC transporter permease LivM -
ORG43_RS01390 (306693) 306693..307460 + 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T264509 WP_000369560.1 NZ_CP110934:302013-302531 [Salmonella enterica]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT264509 WP_001275017.1 NZ_CP110934:301740-302009 [Salmonella enterica]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References