264508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 191830..192590 Replicon chromosome
Accession NZ_CP110934
Organism Salmonella enterica strain CVCC 519

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag ORG43_RS00895 Protein ID WP_000533909.1
Coordinates 192105..192590 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag ORG43_RS00890 Protein ID WP_000965886.1
Coordinates 191830..192117 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORG43_RS00865 (186919) 186919..187221 + 303 WP_000605590.1 YsaB family lipoprotein -
ORG43_RS00870 (187360) 187360..188271 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
ORG43_RS00875 (188281) 188281..190350 + 2070 WP_001291737.1 glycine--tRNA ligase subunit beta -
ORG43_RS00880 (190612) 190612..191013 + 402 Protein_174 IS3 family transposase -
ORG43_RS00885 (191185) 191185..191652 + 468 WP_000702450.1 GNAT family N-acetyltransferase -
ORG43_RS00890 (191830) 191830..192117 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
ORG43_RS00895 (192105) 192105..192590 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
ORG43_RS00905 (194276) 194276..194815 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
ORG43_RS00910 (194989) 194989..195201 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
ORG43_RS00915 (195489) 195489..195779 - 291 WP_000455790.1 HTH-type transcriptional regulator -
ORG43_RS00920 (196218) 196218..196928 + 711 WP_001541097.1 DUF3053 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T264508 WP_000533909.1 NZ_CP110934:192105-192590 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT264508 WP_000965886.1 NZ_CP110934:191830-192117 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References