Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2252490..2253166 Replicon chromosome
Accession NZ_CP110921
Organism Methylococcus sp. 16-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OOT43_RS10565 Protein ID WP_266020540.1
Coordinates 2252490..2252897 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OOT43_RS10570 Protein ID WP_266020541.1
Coordinates 2252894..2253166 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOT43_RS10540 (OOT43_10540) 2247708..2248682 - 975 WP_266020537.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
OOT43_RS10545 (OOT43_10545) 2248778..2249692 + 915 WP_266020538.1 oxygen-dependent coproporphyrinogen oxidase -
OOT43_RS10550 (OOT43_10550) 2249687..2250337 - 651 WP_266020539.1 ABC transporter substrate-binding protein -
OOT43_RS10555 (OOT43_10555) 2250452..2251456 + 1005 WP_266024888.1 porphobilinogen synthase -
OOT43_RS10560 (OOT43_10560) 2251453..2252292 + 840 WP_266024889.1 shikimate dehydrogenase -
OOT43_RS10565 (OOT43_10565) 2252490..2252897 - 408 WP_266020540.1 type II toxin-antitoxin system VapC family toxin Toxin
OOT43_RS10570 (OOT43_10570) 2252894..2253166 - 273 WP_266020541.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OOT43_RS10575 (OOT43_10575) 2253315..2253659 - 345 WP_266020542.1 phenylpyruvate tautomerase MIF-related protein -
OOT43_RS10580 (OOT43_10580) 2253862..2254221 + 360 WP_266020543.1 MbcA/ParS/Xre antitoxin family protein -
OOT43_RS10585 (OOT43_10585) 2254287..2254970 + 684 WP_266020544.1 RES family NAD+ phosphorylase -
OOT43_RS10590 (OOT43_10590) 2255017..2255556 - 540 WP_266020545.1 transposase -
OOT43_RS10595 (OOT43_10595) 2256092..2256871 - 780 WP_266020546.1 hypothetical protein -
OOT43_RS10600 (OOT43_10600) 2257071..2257613 - 543 WP_266024891.1 gamma carbonic anhydrase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-120)

Antitoxin

SpoVT-AbrB domain

(10-37)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14985.74 Da        Isoelectric Point: 9.4601

>T264487 WP_266020540.1 NZ_CP110921:c2252897-2252490 [Methylococcus sp. 16-5]
MSVLHMLDTDIASYVIKGRSPAVEAKLMAIVPSMVCISAVTRAELMYGLKRLLAGHRLHLAVRRFLKIVRVLSWDAEAAD
YYADIRHQLVSTGQPIGEMDMMIAAHSLSAGAMLVTNNVRHYSRIEAPLLLVNWA

Download         Length: 408 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10059.25 Da        Isoelectric Point: 4.2503

>AT264487 WP_266020541.1 NZ_CP110921:c2253166-2252894 [Methylococcus sp. 16-5]
MPETRIAKLFKNGASQAVRLPAEFRFEGDEVYATRDEATGDVVLSSRPGAKTWGDFFELLHSIEVPEDFMAERPMNVVPA
ERDVFGGEEP

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References