Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 1772413..1773080 Replicon chromosome
Accession NZ_CP110921
Organism Methylococcus sp. 16-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag OOT43_RS08225 Protein ID WP_266024377.1
Coordinates 1772413..1772838 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OOT43_RS08230 Protein ID WP_266024378.1
Coordinates 1772835..1773080 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OOT43_RS08200 (OOT43_08200) 1767439..1767906 - 468 WP_266024371.1 cysteine rich repeat-containing protein -
OOT43_RS08205 (OOT43_08205) 1768205..1768888 + 684 WP_266024372.1 protein-methionine-sulfoxide reductase heme-binding subunit MsrQ -
OOT43_RS08210 (OOT43_08210) 1769170..1769799 - 630 WP_266024374.1 hypothetical protein -
OOT43_RS08215 (OOT43_08215) 1770099..1770425 - 327 WP_266024375.1 hypothetical protein -
OOT43_RS08220 (OOT43_08220) 1771709..1771939 + 231 WP_266024376.1 DUF1353 domain-containing protein -
OOT43_RS08225 (OOT43_08225) 1772413..1772838 - 426 WP_266024377.1 type II toxin-antitoxin system VapC family toxin Toxin
OOT43_RS08230 (OOT43_08230) 1772835..1773080 - 246 WP_266024378.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OOT43_RS08235 (OOT43_08235) 1773303..1773656 + 354 WP_266024379.1 DUF1778 domain-containing protein -
OOT43_RS08240 (OOT43_08240) 1773954..1774136 + 183 WP_266024858.1 hypothetical protein -
OOT43_RS08245 (OOT43_08245) 1774415..1776556 + 2142 WP_266024380.1 hypothetical protein -
OOT43_RS08250 (OOT43_08250) 1777220..1777612 + 393 WP_266024381.1 DUF4440 domain-containing protein -
OOT43_RS08255 (OOT43_08255) 1777694..1777927 - 234 WP_266024382.1 addiction module protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-65)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15558.01 Da        Isoelectric Point: 4.9058

>T264485 WP_266024377.1 NZ_CP110921:c1772838-1772413 [Methylococcus sp. 16-5]
VSYLLDTCVLSELRKPAPDPNVTAWVEAVDESRLFISVIVLGEIQKGIAKLEDARRSQVLQLWLEQDLQGRFEGRILPVN
AAVALEWGVLQGSAAKSGLSLPVIDSLIGATAVCHNLTLVTRNTADFERMPVRLLNPWVRE

Download         Length: 426 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9083.37 Da        Isoelectric Point: 6.2852

>AT264485 WP_266024378.1 NZ_CP110921:c1773080-1772835 [Methylococcus sp. 16-5]
MCWQLQEAKNKLSEVIQAAQKSGPQAITVRGRETAVILSAEDYRRLTMKSGSLVSFFQASPWAEVELDLTRSKDVGRDIE
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References