264481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 7437..7911 Replicon plasmid pCF1807-6
Accession NZ_CP110895
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name pasB Uniprot ID S1DZ70
Locus tag OQW59_RS28140 Protein ID WP_000262326.1
Coordinates 7437..7703 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag OQW59_RS28145 Protein ID WP_000879771.1
Coordinates 7687..7911 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS28120 (OQW59_28120) 2704..3135 + 432 WP_053274236.1 DUF6530 family protein -
OQW59_RS28125 (OQW59_28125) 3227..3733 + 507 WP_265970816.1 hypothetical protein -
OQW59_RS28130 (OQW59_28130) 3730..4335 - 606 WP_265969940.1 recombinase family protein -
OQW59_RS28135 (OQW59_28135) 4430..7327 + 2898 WP_001553819.1 Tn3-like element Tn5403 family transposase -
OQW59_RS28140 (OQW59_28140) 7437..7703 - 267 WP_000262326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OQW59_RS28145 (OQW59_28145) 7687..7911 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
OQW59_RS28150 (OQW59_28150) 8457..8645 + 189 WP_000165998.1 Rop family plasmid primer RNA-binding protein -
OQW59_RS28155 (OQW59_28155) 8693..8893 - 201 WP_024148903.1 hypothetical protein -
OQW59_RS28160 (OQW59_28160) 10065..10496 + 432 WP_053274236.1 DUF6530 family protein -
OQW59_RS28165 (OQW59_28165) 10588..11094 + 507 WP_265970816.1 hypothetical protein -
OQW59_RS28170 (OQW59_28170) 11091..11696 - 606 WP_265969940.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..13336 13336
- inside IScluster/Tn - - 3730..13221 9491


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10385.00 Da        Isoelectric Point: 9.5211

>T264481 WP_000262326.1 NZ_CP110895:c7703-7437 [Citrobacter freundii]
MVWTINYSDRALKSLRKMDKQNARRIVDFMDLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRILCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT264481 WP_000879771.1 NZ_CP110895:c7911-7687 [Citrobacter freundii]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1DZ70

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References