Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4971721..4972337 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag OQW59_RS27260 Protein ID WP_003028682.1
Coordinates 4971721..4972095 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag OQW59_RS27265 Protein ID WP_043018956.1
Coordinates 4972095..4972337 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS27245 (4969224) 4969224..4970126 + 903 WP_003847898.1 formate dehydrogenase O subunit beta -
OQW59_RS27250 (4970123) 4970123..4970758 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
OQW59_RS27255 (4970755) 4970755..4971684 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
OQW59_RS27260 (4971721) 4971721..4972095 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
OQW59_RS27265 (4972095) 4972095..4972337 - 243 WP_043018956.1 CopG family transcriptional regulator Antitoxin
OQW59_RS27270 (4972543) 4972543..4973451 + 909 WP_003847901.1 alpha/beta hydrolase -
OQW59_RS27275 (4973602) 4973602..4974543 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
OQW59_RS27280 (4974588) 4974588..4975025 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
OQW59_RS27285 (4975022) 4975022..4975894 - 873 WP_060854619.1 virulence factor BrkB family protein -
OQW59_RS27290 (4975888) 4975888..4976487 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T264479 WP_003028682.1 NZ_CP110894:c4972095-4971721 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT264479 WP_043018956.1 NZ_CP110894:c4972337-4972095 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References