Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4220446..4221100 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag OQW59_RS23610 Protein ID WP_003026936.1
Coordinates 4220446..4220853 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag OQW59_RS23615 Protein ID WP_003026938.1
Coordinates 4220834..4221100 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS23590 (4216389) 4216389..4218122 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
OQW59_RS23595 (4218128) 4218128..4218841 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OQW59_RS23600 (4218870) 4218870..4219766 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
OQW59_RS23605 (4219880) 4219880..4220401 + 522 WP_003026933.1 flavodoxin FldB -
OQW59_RS23610 (4220446) 4220446..4220853 - 408 WP_003026936.1 protein YgfX Toxin
OQW59_RS23615 (4220834) 4220834..4221100 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
OQW59_RS23620 (4221357) 4221357..4222337 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
OQW59_RS23625 (4222431) 4222431..4223090 - 660 WP_003838267.1 hemolysin III family protein -
OQW59_RS23630 (4223253) 4223253..4223564 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
OQW59_RS23635 (4223617) 4223617..4224345 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
OQW59_RS23640 (4224466) 4224466..4225899 + 1434 WP_148374026.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T264477 WP_003026936.1 NZ_CP110894:c4220853-4220446 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT264477 WP_003026938.1 NZ_CP110894:c4221100-4220834 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References