Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4143481..4144142 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag OQW59_RS23215 Protein ID WP_048997879.1
Coordinates 4143481..4143804 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A241Q747
Locus tag OQW59_RS23220 Protein ID WP_048997880.1
Coordinates 4143825..4144142 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS23205 (4139424) 4139424..4141886 - 2463 WP_265867874.1 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA -
OQW59_RS23210 (4142703) 4142703..4143239 + 537 WP_086529874.1 GNAT family N-acetyltransferase -
OQW59_RS23215 (4143481) 4143481..4143804 - 324 WP_048997879.1 TA system toxin CbtA family protein Toxin
OQW59_RS23220 (4143825) 4143825..4144142 - 318 WP_048997880.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OQW59_RS23225 (4144161) 4144161..4144382 - 222 WP_048997881.1 DUF987 domain-containing protein -
OQW59_RS23230 (4144391) 4144391..4144867 - 477 WP_049016517.1 RadC family protein -
OQW59_RS23235 (4144883) 4144883..4145341 - 459 WP_049016518.1 antirestriction protein -
OQW59_RS23240 (4145444) 4145444..4145683 - 240 WP_048998188.1 DUF905 domain-containing protein -
OQW59_RS23245 (4145761) 4145761..4146171 - 411 WP_048998189.1 hypothetical protein -
OQW59_RS23250 (4146261) 4146261..4146434 - 174 WP_247752792.1 hypothetical protein -
OQW59_RS23255 (4146545) 4146545..4146826 - 282 WP_247752793.1 hypothetical protein -
OQW59_RS23260 (4146878) 4146878..4147414 - 537 WP_048998191.1 DUF4339 domain-containing protein -
OQW59_RS23265 (4147440) 4147440..4148150 - 711 WP_213168078.1 DeoR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12455.32 Da        Isoelectric Point: 6.4624

>T264476 WP_048997879.1 NZ_CP110894:c4143804-4143481 [Citrobacter freundii]
MKSQPATTQRAAKPCLSPVDVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARRDLGLLNRN

Download         Length: 324 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11993.64 Da        Isoelectric Point: 7.6976

>AT264476 WP_048997880.1 NZ_CP110894:c4144142-4143825 [Citrobacter freundii]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGQFSDAECRKLDVAFPYFIRQMESMLTTGELNPRHTHCVTLYR
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A241Q747

References