Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1926286..1926876 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name pemK Uniprot ID A0A0J1NBD3
Locus tag OQW59_RS12100 Protein ID WP_003836692.1
Coordinates 1926544..1926876 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0J1NBD4
Locus tag OQW59_RS12095 Protein ID WP_003836694.1
Coordinates 1926286..1926543 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS12090 (1921773) 1921773..1925672 - 3900 WP_265868936.1 hypothetical protein -
OQW59_RS12095 (1926286) 1926286..1926543 + 258 WP_003836694.1 hypothetical protein Antitoxin
OQW59_RS12100 (1926544) 1926544..1926876 + 333 WP_003836692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OQW59_RS12110 (1927351) 1927351..1928268 + 918 WP_003030855.1 nitrogen assimilation transcriptional regulator NAC -
OQW59_RS12115 (1928370) 1928370..1929320 + 951 WP_003846751.1 HTH-type transcriptional regulator Cbl -
OQW59_RS12125 (1929636) 1929636..1931123 - 1488 WP_003846749.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1910946..1938311 27365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11703.48 Da        Isoelectric Point: 8.5572

>T264470 WP_003836692.1 NZ_CP110894:1926544-1926876 [Citrobacter freundii]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKCLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9428.89 Da        Isoelectric Point: 4.3440

>AT264470 WP_003836694.1 NZ_CP110894:1926286-1926543 [Citrobacter freundii]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NBD3

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1NBD4

References