Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1231923..1232543 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag OQW59_RS08825 Protein ID WP_002892050.1
Coordinates 1231923..1232141 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag OQW59_RS08830 Protein ID WP_003021733.1
Coordinates 1232169..1232543 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS08790 (1227156) 1227156..1227785 + 630 WP_016149709.1 membrane protein -
OQW59_RS08795 (1227850) 1227850..1228203 + 354 WP_003831033.1 DUF1428 family protein -
OQW59_RS08800 (1228255) 1228255..1229808 - 1554 WP_265867542.1 EAL domain-containing protein -
OQW59_RS08805 (1229997) 1229997..1230257 + 261 WP_003021719.1 type B 50S ribosomal protein L31 -
OQW59_RS08810 (1230259) 1230259..1230399 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
OQW59_RS08815 (1230478) 1230478..1230948 - 471 WP_003021724.1 YlaC family protein -
OQW59_RS08820 (1231065) 1231065..1231616 - 552 WP_032936967.1 maltose O-acetyltransferase -
OQW59_RS08825 (1231923) 1231923..1232141 - 219 WP_002892050.1 HHA domain-containing protein Toxin
OQW59_RS08830 (1232169) 1232169..1232543 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
OQW59_RS08835 (1233032) 1233032..1236181 - 3150 WP_265970545.1 efflux RND transporter permease AcrB -
OQW59_RS08840 (1236204) 1236204..1237397 - 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T264469 WP_002892050.1 NZ_CP110894:c1232141-1231923 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT264469 WP_003021733.1 NZ_CP110894:c1232543-1232169 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References