Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 578151..578667 Replicon chromosome
Accession NZ_CP110894
Organism Citrobacter freundii strain CF1807

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag OQW59_RS05830 Protein ID WP_003839578.1
Coordinates 578383..578667 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag OQW59_RS05825 Protein ID WP_003839576.1
Coordinates 578151..578393 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQW59_RS05805 (573166) 573166..574299 + 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -
OQW59_RS05810 (574283) 574283..575401 + 1119 WP_003025770.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OQW59_RS05815 (575398) 575398..576138 + 741 WP_003025772.1 KDGP aldolase family protein -
OQW59_RS05820 (576160) 576160..578073 + 1914 WP_213169412.1 BglG family transcription antiterminator -
OQW59_RS05825 (578151) 578151..578393 + 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OQW59_RS05830 (578383) 578383..578667 + 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OQW59_RS05835 (578671) 578671..579135 - 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OQW59_RS05840 (579242) 579242..581380 - 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
OQW59_RS05845 (581758) 581758..582342 - 585 WP_213169125.1 fructose PTS transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T264468 WP_003839578.1 NZ_CP110894:578383-578667 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT264468 WP_003839576.1 NZ_CP110894:578151-578393 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References